ShuimuBio is an evolving cryo-EM & AI platform empowering faster drug discovery via harnessing structural insights of difficult-to-crystallize biological targets.

ShuimuBio is an evolving cryo-EM & AI platform empowering faster drug discovery via harnessing structural insights of difficult-to-crystallize biological targets.

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Leverage cryo-EM & AI to accelerate and push the boundaries of modern-day drug discovery.

“Biochemical maps have long been filled with blank spaces because the available technology has had difficulty generating images of much of life‘s molecular machinery. Cryo-electron microscopy changes all of this.” Cryo-EM is revealing structures of medically relevant biomolecules at an ever-increasing pace, reshaping the drug discovery landscape. By integrating AI into the process of cryo-EM-enabled drug discovery, we are dramatically accelerating early drug R&D.

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See unseeable. Drug undruggable.

Most of the validated biological molecule targets of next-generation drugs such as transmembrane receptors (e.g., GPCRs) and dynamic complexes are proteins notoriously difficult to crystallize, raising a high bar for scientists to obtain their structures through the traditional crystallography method. Our advanced 300kV cryo-EM platform opens the door to many of these targets, acquiring their structures at near-atomic resolution, and thus turning them into seeable and druggable targets.

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Boost structure accuracy and resolution via top-notch AI.

A high-accuracy molecule structure model of the biological target at atomic resolution is critical to a successful structure-based drug discovery effort. While a seasoned structure biologist is capable of constructing reasonably reliable structures, structure determination is still a complex task and humans have limitations. We are incorporating deep learning to rapidly improve model accuracy and map resolution.

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Speed up everything with ShuimuBio powered cryo-EM computing platform.

As cryo-EM quickly becomes the most preferred technology for structural characterization and candidate screening, the throughput is required to facilitate faster drug discovery. We are dedicated to providing the most powerful cryo-EM computing platform in the world, making high-throughput cryo-EM a new norm. During the Omicron outbreak, dozens of Omicron antigen-antibody complex structures have been successfully resolved by us (highest resolution at 2.5Å) within a few days.

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Be the first, not the better.

We are ready to team up with aspiring partners who are determined to bring first-in-class drugs and pioneer neo therapies to the world. Combining Cryo-EM and AI technology, we make the previously impossible ideas possible. “It is very easy to answer many fundamental biological questions: you just look at the thing.” Let's unveil the mysteries and make the most impactful breakthroughs.

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CONTACT
SHUIMUBIO

Hi@shuimubio.com
+ 86 18510728199

B1,National Institute of Biological Sciences,
Changping Beijing, PR China

公众号

Please contact us if you
have any needs

S U B M I T

Leverage cryo-EM & AI to accelerate and push the boundaries of modern-day drug discovery.

“Biochemical maps have long been filled with blank spaces because the available technology has had difficulty generating images of much of life‘s molecular machinery. Cryo-electron microscopy changes all of this.” Cryo-EM is revealing structures of medically relevant biomolecules at an ever-increasing pace, reshaping the drug discovery landscape. By integrating AI into the process of cryo-EM-enabled drug discovery, we are dramatically accelerating early drug R&D.

01

See unseeable. Drug undruggable.

Most of the validated biological molecule targets of next-generation drugs such as transmembrane receptors (e.g., GPCRs) and dynamic complexes are proteins notoriously difficult to crystallize, raising a high bar for scientists to obtain their structures through the traditional crystallography method. Our advanced 300kV cryo-EM platform opens the door to many of these targets, acquiring their structures at near-atomic resolution, and thus turning them into seeable and druggable targets.

02
Hold

Boost structure accuracy and resolution via top-notch AI.

A high-accuracy molecule structure model of the biological target at atomic resolution is critical to a successful structure-based drug discovery effort. While a seasoned structure biologist is capable of constructing reasonably reliable structures, structure determination is still a complex task and humans have limitations. We are incorporating deep learning to rapidly improve model accuracy and map resolution.

03

Speed up everything with ShuimuBio powered cryo-EM computing platform.

As cryo-EM quickly becomes the most preferred technology for structural characterization and candidate screening, the throughput is required to facilitate faster drug discovery. We are dedicated to providing the most powerful cryo-EM computing platform in the world, making high-throughput cryo-EM a new norm. During the Omicron outbreak, dozens of Omicron antigen-antibody complex structures have been successfully resolved by us (highest resolution at 2.5Å) within a few days.

04

Be the first, not the better.

We are ready to team up with aspiring partners who are determined to bring first-in-class drugs and pioneer neo therapies to the world. Combining Cryo-EM and AI technology, we make the previously impossible ideas possible. “It is very easy to answer many fundamental biological questions: you just look at the thing.” Let's unveil the mysteries and make the most impactful breakthroughs.

05
contact

Please contact us if you
have any needs

S U B M I T

Contact

  • E-mail: Hi@shuimubio.com
  • Contact a Specialist: +1 (617) 5993866

Address | ShuimuBio HQ

F4, Bio² Innovation Center, Life Science Park,
Changping District, Beijing, PR China

Address | ShuimuBio CryoEM Center

B1, National Institute of Biological Sciences,
Changping District, Beijing, PR China

  • E-mail: Hi@shuimubio.com
  • Contact a Specialist: +1 (617) 5993866

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